| (EJVP Vol4 No 2; page 98 Case 2)
Histopathology Case
Tissue from a goat
 Figure1  Figure 2
 Figure 3
 Figure 4
Questions:
A: Histopathological description:
B: What is the morphological diagnosis?
C: What is the aetiologic agent?
ANSWERS
A: Histopathological description:
Brain stem contains multiple coalescing foci of microabscessation with mostly degenerated neutrophils and lesser numbers of lymphocytes, macrophages and plasma cells. Adjacent parenchyma shows mild diffuse infiltration of lymphocytes and glial actication, also edema, neuronal degeneration, axonal swelling and a prominent vaculature due to endothelial hypertrophy. Rarefaction of the parenchyma with gitter cell infiltration is also evident. The perivascular spaces are extended by variably thick cuffs of mainly lymphocytes and macrophages and fewer neutrophils, which additionally obscure vessel walls due to migration. There is rarely myointimal degeneration of small arteries. A mild diffuse lyphohistiocytic meningitis is present. Occasional faintly basophilic, dust-like particles present within macrophages are interpreted as intracellular bacteria.
B: Morphological Diagnosis:
Multifocal, severe, subacute, lymphohistiocytic encephalitis with microabscesses and mild lymphohistiocytic meningitis.
C: Aetiologic agent:
Listeria monocytogenes
Other Questions
|
