(EJVP Vol5 No 1; page 37 Case 2)
Histopathological Case
Tissue from a pig
   
QUESTIONS:
A: Provide a histopathological description
B: What is your morphological diagnosis?
C: Name the disease
D: Name the associated infectious agent
ANSWERS:
A: Histopathological description:
Ileum: villi are blunted, club shaped and have expansion of the lamina propria by aggregates of epithelioid macrophages, histiocytes, lower numbers of eosinophils, lymphocytes and neutrophils. Lamina proprial and submucosal blood vessels are congested. The superficial submucosa is infiltrated by epithelioid macrophages, few lymphocytes, plasma cells and eosinophils. Peyer's patches have multifocal granulomatous inflammation characterised by coalescing foci of histiocytes, epithelioid macrophages and multinucleate giant cells that are scattered throughout the parenchyma and replace normal architecture. Follicular centres of lymphoid nodules of Peyer's patches are depleted and necrotic containing karyorrhectic debris. Epithelioid macrophages, multinucleate giant cells, and fewer lymphocytes and eosinophils surround necrotic areas. Large numbers of histiocytes, epithelioid macrophages and multinucleate giant cells that contain variable numbers of intracytoplasmic inclusion bodies are multofocally distributed in clusters within areas of granulomatous inflammation. The intracytoplasmic inclusions are round, homogeneous, magenta-to-basophilic, variable i size (5-25um) and are single or form botryoid clusters.
B: Morphological diagnosis:
Ileum (Peyer's patches); lymphadenitis; severe diffuse, granulomatous with intralesional intracytoplasmic inclusion bodies
C: Disease: Postweaning Multosystemic Wasting Syndrome
D: Associated infectious agent: Porcine Circovirus
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