| (EJVP Vol5 No 3; page 115 Case 2)
Histopathology Case
Tissue (eye) from a cat
1a: choroidea with adjacent tissue
1b/c: higher magnification of 1a
2: ciliary body
3: retina
4a/b: optic nerve
QUESTIONS:
A: Histopathological description
B: What is the morpholigical diagnosis?
C: Name the disease
D: Name the aetiological agent
ANSWERS:
A: In the choroidea, focal, predominantly mononuclear infiltrates (macrophages and a few lymphocytes) and single neutrophils are seen. The retina is detached from the choroidea, and the retinal epithelium is hypertrophic. The adjacent tissue exhibits a mononuclear vasculitis with macrphages and lymphocytes and a focal granulomatous infiltrate with numerous macrophages. Single monocytes are seen attaching to the vessel wall. The ciliary body shows marked mononuclear infiltration, dominated by macrophages, accompanied by numerous plasma cells and lymphocytes. The vitreous contains fibrin and a few mononuclear inflammatory cells. In the retina, a granulomatous-necrotising vasculitis is seen. The optic nerve shows moderate perineural infiltration by mononuclear cells, dominated by plasma cells.
B: Marked fibrinous and granulomatous uveitis with granulomatous and necrotising vasculitis in the retina and perichoroideal tissue and retinal detachment with hypertrophy of pigment epithelium; moderate mononuclear perineuritis of the optic nerve.
C: Feline infectious peritonitis
D: Feline infectious peritonitis virus; feline coronavirus; group I coronavirus; coronaviridae; nidovirales
Literature:
Wilcock BP: the eye and ear p 483. In: Jubb KVF, Kennedy PC and Palmer N. 1993: Pathology of domsetic animals, Vol 1, 4th Ed. Academic Press.
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