| (EJVP Vol 7 No 1; page 35)
Tissue from a dog
  
QUESTIONS
A: Histopathological description
B: Morphological diagnosis
C: Name the disease
D: List three predisposed breeds
ANSWERS
A: Histopathological description
Haired skin: In the mid dermis a multifocal, nodular, perifollicularly oriented inflammatory infiltration is present. Inflammation is prevalently located in the dermal area adjacent to the follicular isthmus and involves 95% of the piolosebaceous units. Inflammatory aggregates are often centred around a large empty vacuole with distinct borders (residual lipids or residual sebaceous gland duct) and completely obscure the sebaceous glands. Inflammatory infiltrates are composed of predominantly mature lymphocytes and foamy macrophages with moderate numbers of neutrophils and occasional plasma cells. Multinulceated giant cells with 3 to 6 nuclei, ranging from 2 to 8 per inflammatory aggregate are present.
B: Morphological diagnosis
Haired skin: severe, multifocal, subacute to chronic, granulomatous sebaceous adenitis
C: Name the disease
Sebaceous adenitis
D: List three predisposed breeds
Poodle, Viszla, Akita, (Samoyed, Chow Chow) are predisposed to granulomatous sebaceous adenitis
(Comment: The feature of the disease vary to some degree with the breed affected. While the Viszla has more pronounced granulomatous to pyogranulomatous lesions. the Poodle often shows only a scanty lymphocytic inflammation at the level of the sebaceous ducts in chronic lesions - Scott et al, Small Animal Deermatology; W B Saunders, 2001 p1144)
References
Gross et al; Veterinary Dermatopathology: a macroscopic and microscopic evaluation of canine and feline skin disease. Mosby-Yearbook 1992
Yaeger et al, Color atlas and text of surgical pathology of the dog and cat. Mosby-Yearbook, 1994
Scott 1986 Granulomatous sebaceous adenitis in dogs, J Am An Hosp Assoc, 22, 631-634
Submitted by Dr Roccaabianca; Istituto di Anatomia PatologicaVeterinaria e Patologia Aviare, Universita degli Studi di Milano
Other Questions
|
