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The following questions, and sample answers, are derived from a "mock examination" provided at the University of Giessen in April 2001.
They are illustrative of the different styles used in the examinations but do not necessarily reflect the degree of severity of the actual membership examination.
Question 1. Which of the following cytokines is involved in delayed-type hypersensitivity reactions:
1. IL-2
2. IL-4
3. IFN-gamma
4. IL-13
5. IL-12
(tick box)
 A. 1, 2, 3
B. 1, 3, 5 (correct answer)
C. 1, 3, 4
D. 2, 4, 5
E. 3, 4, 5
(Robbins Cotran and Kumar, 6th edition, 1999, p 204-206)
Question 2. Describe the extrinsic pathway of the coagulation cascade:
Tissue injury, factor VII and tissue factor activate factor X, which with factor V activates factor II = prothrombin, which is cleaved into thrombin, which cleaves fibrinogen into fibrin,
(Robbins Cotran and Kumar, 6th edition, 1999, p121)
Question 3. Insert in column B the correct number for the temporal sequence of cellular events which occur during first intention wound healing in skin.
A Time interval post surgical incision
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<24 hours |
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24-48 hrs |
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day 3 |
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day 5 |
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day 7-14 |
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Cellular events
1. fibrin accumulation
2. neovascularisation is maximal
3. collagen accumulation and fibroblast proliferation
4. neutrophils appear, mitosis of epidermal basal cells, migration and fusion of epithelial cells
5. macrophage invasion, granulation tissue formation
A Time interval post surgical incision
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<24 hours |
1 (fibrin accumulation) |
24-48 hrs |
4 (NLs appear, mitosis of epidermal basal cells, migration and fusion of epithelial cells) |
day 3 |
5 (macrophage invasion, granulation tissue formation) |
day 5 |
2 (neovascularisation is maximal) |
day 7-14 |
3 (collagen accumulation and fibroblast proliferation) |
(Robbins Cotran and Kumar, 6th edition, 1999, pp107-109)
Question 4. List three possible fates of a thrombus.
propagation
embolisation
dissolution
organisation/recnalisation
(Robbins Cotran and Kumar, 6th edition, 1999, p127)
Question 5. Immunologic tolerance is the lack of capability to develop an immune response to a specific antigen. Name two (2) mechanisms of peripheral tolerance.
-clonal deletion
-clonal anergy
-suppression by suppressor T-cells
(Robbins Cotran and Kumar, 6th edition, 1999, p213, 214)
Question 6. Which of the following statements regarding the p73 protein is NOT correct?
(tick box)
A. p73 has a high homology with the tumor suppressor gene p 53.
B. p73 deficient mice exhibit congenital hydrocephalus and hippocampal dysgenesis.
C. p73 deficient mice develop severe rhinitis and purulent otitis media.
D. p73 deficient mice show increased susceptibility to spontaneous tumorigenesis.
E. p73 deficient mice show high mortality rate secondary to gastrointestinal and intracranial bleeding.
D. (correct answer)
p73 deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature, vol. 404: 99-102, 2000
Question 7. Which of the following statements regarding prion proteins is the LEAST correct?
(tick box)
A: PrPC is a glycosylsulfatidylinositol-anchored cell surface protein.
B: PrPSC binds to plasminogen.
C: PrP expression in B-lymphocytes is not required for neuroinvasion.
D: PrP replication in spleen of mice is dependent on follicular dendritic cells.
E: PrPSC is identified with conformation specific monoclonal antibodies
E: (correct answer)
(Science, 15.9.2000, p. 1925)
(Nature, 23.11.200, p 475)
(Nat.Med, 4.12.98, p.1429)
(Science, 19.5.2000, p1257)
Question 8. List the three (3) major classes of cell surface receptors important for cell growth and outline the principal signal transduction pathways for ONE (1) of these classes.
(1) Receptors with intrinsic kinase activity
(2) Receptors without intrinsic catalytic activity
(3) G protein-linked receptors.
(Robbins Cotran and Kumar, 6th edition, 1999, pp92-93
(The components of the individual signal pathways are summarised in Figure 4-4, p93)
Question 9. What is a superantigen?
Polyclonal T-cell activator, can therefore activate many more T-cells compared to normal antigens, which results in massive cytokine production with all consequences.
(Robbins Cotran and Kumar, 6th edition, 1999, p136)
Question 10. Which of the following statements is NOT true?
(tick box)
A. In transgenic mice, a molecular cloned human or animal DNA is introduced into the germ line of suitable mice by injecting it into the ovum
B. In “knocked out” mice the normal genes are replaced by inactive genes
C. The goal of gene therapy is to treat genetic diseases by transfer of somatic cells transfected with the normal gene
D. Hereditary disorders are derived from one’s parents and are transmitted in the somatic line through the generations and therefore are familial
E. The term congenital simply implies “born with”
Robbins Cotran and Kumar, 6th edition, 1999, p140-141.
D: (correct answer)
Example questions from other sections of the ECVP examination:
This page was last updated
April 17, 2005
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Comprehensive Pathology
