| (Small animal, Large animal, Exotic/Wildlife and Laboratory animal Pathology)
The following questions, and sample answers, are derived from a "mock examination" provided at the University of Giessen in April 2001.
They are illustrative of the different styles used in the examinations but do not necessarily reflect the degree of severity of the actual membership examination.
Small Animal Questions
1. Which combination of statements regarding HYPERTROPHIC OSTEOPATHY (HOP) in dogs is CORRECT?
HOP:
1. is characterized by diffuse periosteal osteophytosis
2. develops secondary to a chronic lesion, usually intrathoracic
3. lesions are most prominent on the skull
4. associated bone formation will never exceed the width of the cortex of the pre-existing bone
5. has also been observed in mares with ovarian tumours
(tick box)
 A. 1,2,5 (correct)
B. 1,2,3
C. 3,4,5
D. 1,4,5
E. 1,2,4
(Jubb, Kennedy, Palmer: Vol 1: 116-117)
2. Which of the following findings are typical for FELINE CHONDROMATOSIS?
1. Presence of viral particles resembling FeLV in some tumour cells
2. Immature animals are affected
3. Cranial bones are affected
4. Malignant transformation (e.g.osteosarcoma) can occur
5. Autosomal recessive inheritance
(tick box)
A. 2,4,5
 B. 1,3,5
C. 1,2,4
D. 1,3,4 (correct)
E. 2,3,5
( Jubb, Kennedy, Palmer, Vol 1: 129-130; WHO Tumours of bone and joints p6)
3. Which of the following statements regarding ATROPHIC LYMPHOCYTIC PANCREATITIS of German Shepherd dogs and rough-coated collies are NOT CORRECT?
1. In the subclinical phase of the disease, infiltrative lymphocytic inflammation leads to atrophy of pancreatic acinar tissue.
2. In the subclinical phase of the disease, inflammation results in selective destruction of islet cells.
3. In the subclinical phase of the disease, most infiltrating lymphocytes are CD 4+ T cells.
4. In the subclinical phase of the disease, CD4+ and CD8+ T cells are present in almost equal numbers.
5. In progressive atrophic pancreatitis, B cell lymphoid follicles are a component of the acinar inflammatory process.
(tick box)
A. 1,2,3
B. 1,3,4
C. 3,4,5
D. 3,4
E. 2,3 (correct)
(Vet Immunol Immunopathol (2000) 76: 103-115)
4. Name the main microscopic lesions caused by CANINE ADENOVIRUS (CAV)-2 infection in dogs.
Acute necrotising bronchiolitis with large amphophilic intranuclear inclusions
(JKP Vol 2, 627)
5. Aberrant cuterebral larval migration in the brain is proposed to be the cause of FELINE ISCHEMIC ENCEPHALOPATHY. Name the five characteristic histopathological features of the disease.
Parasitic tract lesion
Superficial laminar cerebrocortical necrosis
Cerebral infarction
Subependymal rarefaction and astrogliosis with/without ependymal cell loss
Subpial astrocytosis
(Veterinary Pathology (1998) 35: 330-343)
6. List 4 canine tumors which are likely to be positive on immunohistochemistry for Chromogranin A?
Pheochromocytoma
Chemodectoma
Islet cell carcinoma
Pituitary adenoma
Parathyroid adenoma
C-cell carcinoma
(Veterinary Pathology (1998) 35: 312-315)
Large Animal Questions
7. Which of the following statements regarding EQUINE RECURRENT UVEITIS (ERU) is NOT CORRECT?
(tick box)
A. Inflammation in ERU primarily involves the ciliary body and non-pigmented ciliary epithelium.
B. Mononuclear cellular infiltrations are dominated by CD8+ lymphocytes. (correct)
C. Experimental uveitis can be induced in horses by bacterial lipopolysaccharides.
D. ERU is a painful ocular inflammation that is the primary cause of blindness in horses.
E. The mechanisms of initiation and perpetuation of ERU are still unknown.
( Vet Immunol Immunopathol (2000) 76: 239-255)
8. Which of the following combination of statements regarding PORCINE DERMATITIS AND NEPHROPATHY SYNDROME (PDNS) is CORRECT?
1. Pigs with PDNS develop epidermal necrosis predominantly on hindlimbs and perineum.
2. Pigs with PDNS develop severe bilateral pyelonephritis.
3. Pigs with PDNS have a systemic necrotising and leukocytoclastic vasculitis suggestive of a type 3 hypersensitivity reaction.
4. Postweaning multisystemic wasting syndrome circovirus appears to be a type-1 virus.
5. Porcine respiratory and reproductive syndrome viral antigens and porcine circovirus have been identified in tissues of pigs with PDNS.
(tick box)
A. 1,2,4
B. 1,3,5 (correct)
C. 2,3,4
D. 3,4,5
E. 1,3,4
( Veterinary Record (2000). 146: 40-43; Veterinary Pathology (1998) 35: 108-116)
9. Which of the following are characteristic histological changes in the brain of pigs with „salt poisoning“?
1. Laminar cerebrocortical necrosis
2. Hydrocephalus
3. Leptomeningeal and parenchymal perivascular infiltration of eosinophils
4. Non-suppurative meningoencephalitis
5. Eosinophilic inclusion bodies in neuronal cytoplasm
(tick box)
A. 1,2
B. 3,4
C. 4,5
D. 1,4
E. 1,3 (correct)
( Summers: Vet Neuropathology pp254-255)
10. Name the main lesion caused by SELENIUM TOXICOSIS in swine.
Focal symmetrical poliomalacia
(JKP Vol 1, 340, )
11. List the main gross and histologic changes of OVINE PROGRESSIVE PNEUMONIA (MAEDI)
Gross:
Lung consolidation (prevalent dorso-caudal, also lungs do not collapse and retain ribs’ impression)
Enlargement of bronchial and mediastinal lymph nodes
Histo:
Perivascular, peribronchial and peribronchiolar lymphoid follicles with germinal centres (lymphoid interstitial pneumonia)
Smooth muscle hyperplasia of the wall of terminal bronchioles and alveolar ducts
Thickening of alveolar septae by lymphocytes and macrophages
(JKP Vol 2, 629-631)
12. In the following diseases of swine, MATCH the lesions with the most likely etiology
Virus |
Lesion |
|
A. Porcine cytomegalovirus |
1. Lymphocytic karyolysis |
|
B. African Swine Fever Virus |
2. Colonic button ulcers |
|
C. Porcine Parvovirus |
3. Abortion and stillbirths |
| D. Encephalomyocarditis Virus |
4. Fetal mummification |
E. Hog cholera virus |
5. Intranuclear inclusion bodies in glandular epithelium of nasal cavity |
Correct answer: A5, B1, C4, D3, E2; ie:
Virus |
Lesion |
A. Porcine cytomegalovirus |
5. Intranuclear inclusion bodies in glandular epithelium of nasal cavity |
B. African Swine Fever Virus |
1. Lymphocytic karyolysis |
C. Porcine Parvovirus |
4. Fetal mummification |
D. Encephalomyocarditis Virus |
3. Abortion and stillbirths |
E. Hog cholera virus |
2. Colonic button ulcers |
(Jones Hunt and King, pp238, 249, 298, 263, 270)
Exotic/Laboratory Animals
Exotics
13. Which of the following statements regarding cardiovascular flukes in stranded green turtles is NOT correct?
(tick box)
A. Lesions caused by fluke eggs are most prominent in the heart and lung. (correct)
B. Lesions consist of multifocal granulomas.
C. Several species of spirochid have been identified.
D. Severe disease due to fluke infection was implicated as the principal cause of death in approximately 10% of stranded green turtles in Australia.
E. Cardiovascular fluke associated lesions include mural endocarditis and arteritis.
( Veterinary Pathology (1998) 35: 21-30)
14. Gazelle Herpes Virus-1 infection of Thomson’s gazelles is characterized by:
1. Vasculitis and infarction
2. Macroscopic lesions in brain and spinal cord
3. Neuronal degeneration and inclusion bodies
4. Similarities to changes found in experimental Equine Herpes Virus-1 infection in llamas
5. Lack of similarity to changes in Equine Herpes Virus-1 infection in horses
(tick box)
A. 1,2,3
B. 2,3,4
C. 3,4,5 (correct)
D. 1,4,5
E. 1,2,5
( J.Comp. Pathol. (1998) 119)
15. All of the following events occur in Ricin toxicity in Rhesus monkeys EXCEPT:
(tick box)
A. Fibrinopurulent pneumonia
B. Inactivation of cellular 60S ribosomal subunits
C. Purulent mediastinal lymphadenitis
D. Sudden onset of diarrhoea (correct)
E. Binding of lectin moiety of toxin to cell surface receptor glycoproteins
(Veterinary Pathology (1996) 33: p 296 )
16. List five macroscopic lesions observed in SYSTEMIC ADENOVIRUS INFECTION of black-tailed deer.
(Any 5 from:)
Intense pulmonary oedema
Haemorrhagic enteropathy
Necroulcerative oral lesions
Haemorrhage in pulmonary artery
Endocardial haemorrhage
Glossal infarction
Pharyngeal abscesses
(Veterinary Pathology (1999) 36:100-110)
Laboratory Animals
17. List the macroscopic lesions caused by CLOSTRIDIUM PILIFORME (BACILLUS PILIFORMIS) in gerbils.
Transmural necrotising enteritis and/or typhlitis
Multifocal necrotising hepatitis
Multifocal necrotising myocarditis
(POLA Notes, Disease of gerbils, 1999; Percy and Barthold, Pathology of Laboratory Rodents and Rabbits, pp 138-139 (1st Ed))
18. The following questions relate to tidemark separation in hamsters.
A. What does the tidemark divide?
Articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer
B. What may be the longterm result of tidemark defects
Osteoarthrosis-like cartilage lesions
C. Where are the lesions almost exclusively found?
Tibia
D. What age group of hamster exhibits pathological lesions?
Older than 90 days (an alternative is older than 123 days)
(Veterinary Pathology (1999) 36: 138-145)
Example questions from other sections of the ECVP examination:
This page was last updated
April 17, 2005
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Comprehensive Pathology
